Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.

Journal of cell science - 15 Jul 2009

Hamaratoglu Fisun, Gajewski Kathleen, Sansores-Garcia Leticia, Morrison Clayton, Tao Chunyao, Halder Georg

Abstract excerpt

The Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes the Fat cadherin, a transmembrane protein, which acts upstream of several other components that form a kinase cascade that culminates in the regulation of gene expression through the transcriptional coactivator Yorkie (Yki). Our previous work in Drosophila...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Neurofibromin 2

Share to Protein Kinase C

Share to Wings, Animal

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19531584
DOI: 10.1242/jcs.046482
PMCID: PMC2704875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.PMID 19531584Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

The Hippo pathway regulates apical-domain size independently of its growth-control function.Semantic proximity Read ↗

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

Endocytic control of epithelial polarity and proliferation in Drosophila.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read ↗

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.