Article
Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice.
PloS one - 1 Jan 2012
Rateri Debra L, Moorleghen Jessica J, Knight Victoria, Balakrishnan Anju, Howatt Deborah A, Cassis Lisa A, Daugherty Alan
Abstract excerpt
BACKGROUND: Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal aortic aneurysms (AAAs). However, the role of AT1a receptor stimulation of principal cell types resident in the arterial wall remains undefined. Therefore, the aim of this study was to determine whether deletion of AT1a receptors in either...
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