Article
KRAS mutations: analytical considerations.
Clinica chimica acta; international journal of clinical chemistry - 20 Apr 2014
Herreros-Villanueva Marta, Chen Chih-Chieh, Yuan Shyng-Shiou F, Liu Ta-Chih, Er Tze-Kiong
Abstract excerpt
Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer death globally. Significant improvements in survival have been made in patients with metastasis by new therapies. For example, Cetuximab and Panitumumab are monoclonal antibodies that inhibit the epidermal growth receptor (EGFR). KRAS mutations in codon 12 and 13 are the recognized biomarkers that are analyzed in...
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