Article
Comparison of KRAS mutation tests in colorectal cancer patients.
Genetic testing and molecular biomarkers - 1 Nov 2011
Hancer Veysel Sabri, Buyukdogan Murat, Türkmen Ilknur, Bassullu Nuray, Altug Tuncay, Diz-Kucukkaya Reyhan, Bulbul-Dogusoy Gulen, Demir Gokhan
Abstract excerpt
The KRAS pathway and studies evaluating KRAS as a prognostic marker in colorectal cancer are discussed along with advances in KRAS gene mutation testing. Highly sensitive real-time polymerase chain reaction (PCR) methods were developed for this purpose. We examined the applicability of direct sequencing and two real-time PCR methods in the diagnosis of KRAS mutations. We used real-time PCR and direct...
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