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Article

Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.

PLoS genetics - 26 Mar 2010

Zhou Hongxia, Huang Cao, Chen Han, Wang Dian, Landel Carlisle P, Xia Pedro Yuxing, Bowser Robert, Liu Yong-Jian, Xia Xu Gang

Abstract excerpt

TDP-43 proteinopathies have been observed in a wide range of neurodegenerative diseases. Mutations in the gene encoding TDP-43 (i.e., TDP) have been identified in amyotrophic lateral sclerosis (ALS) and in frontotemporal lobe degeneration associated with motor neuron disease. To study the consequences of TDP mutation in an intact system, we created transgenic rats expressing normal human TDP or a mutant form of...

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Identifiers

PMID: 20361056
DOI: 10.1371/journal.pgen.1000887
PMCID: PMC2845661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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