Article
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica - 1 Jul 2013
Clippinger Amy K, D'Alton Simon, Lin Wen-Lang, Gendron Tania F, Howard John, Borchelt David R, Cannon Ashley, Carlomagno Yari, Chakrabarty Paramita, Cook Casey, Golde Todd E, Levites Yona, Ranum Laura, Schultheis Patrick J, Xu Guilian, Petrucelli Leonard, Sahara Naruhiko, Dickson Dennis W, Giasson Benoit, Lewis Jada
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) has been subdivided based on the main pathology found in the brains of affected individuals. When the primary pathology is aggregated, hyperphosphorylated tau, the pathological diagnosis is FTLD-tau. When the primary pathology is cytoplasmic and/or nuclear aggregates of phosphorylated TAR-DNA-binding protein (TDP-43), the pathological diagnosis is FTLD-TDP. Notably, TDP-43...
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