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Article

Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study.

Rheumatology (Oxford, England) - 1 Nov 2010

Posthumus Michael, Collins Malcolm, Cook Jill, Handley Christopher J, Ribbans William J, Smith Roger K W, Schwellnus Martin P, Raleigh Stuart M

Abstract excerpt

OBJECTIVES: Achilles tendon pathology is a multifactorial condition for which various risk factors, including genetic factors, have been identified. Gene transfection of two members of the TGF-β family, TGF-β1 and growth/differentiation factor-5 (GDF-5), have been shown to enhance tendon repair and mechanical strength within animal Achilles tendon injury models. The objective of this study was to investigate...

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Source

Identifiers

PMID: 20360039
DOI: 10.1093/rheumatology/keq072

Genes

GDF5
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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