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Article

Altered expression of proteoglycan, collagen and growth factor genes in a TGF-β1 stimulated genetic risk model for musculoskeletal soft tissue injuries.

Journal of science and medicine in sport - 1 Aug 2020

Willard Kyle, Laguette Mary-Jessica Nancy, Alves de Souza Rios Leonardo, D'Alton Caroline, Nel Melissa, Prince Sharon, Collins Malcolm, September Alison Victoria

Abstract excerpt

OBJECTIVES: To investigate the functional effect of implicated variants within BGN and COL5A1 on gene expression of components of the extracellular matrix (ECM) in a TGF-β-stimulated risk model for musculoskeletal soft tissue injuries. DESIGN: Experimental research, laboratory study. METHODS: Skin biopsies were obtained from nine healthy participants with either a combined increased or reduced risk profile for...

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Identifiers

PMID: 32061523
DOI: 10.1016/j.jsams.2020.02.007

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