Genetic and Epigenetic Fine-Tuning of TGFB1 Expression Within the Human Osteoarthritic Joint.

doi:10.1002/art.41736

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Article

Genetic and Epigenetic Fine-Tuning of TGFB1 Expression Within the Human Osteoarthritic Joint.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2021

Rice Sarah J, Roberts Jack B, Tselepi Maria, Brumwell Abby, Falk Julia, Steven Charlotte, Loughlin John

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) is an age-related disease characterized by articular cartilage degeneration. It is largely heritable, and genetic screening has identified single-nucleotide polymorphisms (SNPs) marking genomic risk loci. One such locus is marked by the G>A SNP rs75621460, downstream of TGFB1. This gene encodes transforming growth factor β1, the correct expression of which is essential for cartilage...

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PMID: 33760378
DOI: 10.1002/art.41736

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