Article
A pathway-based approach investigating the genes encoding interleukin-1β, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy.
British journal of sports medicine - 1 Oct 2011
September Alison V, Nell Erica-Mari, O'Connell Kevin, Cook Jill, Handley Christopher J, van der Merwe Lize, Schwellnus Martin, Collins Malcolm
Abstract excerpt
OBJECTIVES: Achilles tendinopathy (AT) is a multifactorial condition for which genetic risk factors have been identified. A pathway-based approach was used to investigate genes within the inflammatory pathway. METHODS: Functional polymorphisms within IL-1β (-31T→C and -511C→T), IL-1RN (variable number tandem repeat) and IL-6 (-172G→C) were investigated for associations with AT in a South African (SA) and...
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