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Article

Exploring new genetic variants within COL5A1 intron 4-exon 5 region and TGF-β family with risk of anterior cruciate ligament ruptures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2020

Laguette Mary-Jessica N, Barrow Kelly, Firfirey Firzana, Dlamini Senanile, Saunders Colleen J, Dandara Collet, Gamieldien Junaid, Collins Malcolm, September Alison V

Abstract excerpt

Variants within genes encoding structural and regulatory elements of ligaments have been associated with musculoskeletal soft tissue injury risk. The role of intron 4-exon 5 variants within the α1 chain of type V collagen (COL5A1) gene and genes of the transforming growth factor-β (TGF-β) family, TGFBR3 and TGFBI, was investigated on the risk of anterior cruciate ligament (ACL) ruptures. A case-control genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31922278
DOI: 10.1002/jor.24585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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