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Article

Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease.

BMC medical genetics - 1 Apr 2010

Simon David K, Pankratz Nathan, Kissell Diane K, Pauciulo Michael W, Halter Cheryl A, Rudolph Alice, Pfeiffer Ronald F, Nichols William C, Foroud Tatiana

Abstract excerpt

BACKGROUND: Mitochondrial function is impaired in Parkinson's disease (PD) and may contribute to the pathogenesis of PD, but the causes of mitochondrial impairment in PD are unknown. Mitochondrial dysfunction is recapitulated in cell lines expressing mitochondrial DNA (mtDNA) from PD patients, implicating mtDNA variants or mutations, though the role of mtDNA variants or mutations in PD risk remains unclear. We...

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Identifiers

PMID: 20356410
DOI: 10.1186/1471-2350-11-53
PMCID: PMC2858137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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