Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians.

doi:10.1038/sj.ejhg.5201425

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Article

Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians.

European journal of human genetics : EJHG - 1 Jun 2005

Ghezzi Daniele, Marelli Cecilia, Achilli Alessandro, Goldwurm Stefano, Pezzoli Gianni, Barone Paolo, Pellecchia Maria Teresa, Stanzione Paolo, Brusa Livia, Bentivoglio Anna Rita, Bonuccelli Ubaldo, Petrozzi Lucia, Abbruzzese Giovanni, Marchese Roberta, Cortelli Pietro, Grimaldi Daniela, Martinelli Paolo, Ferrarese Carlo, Garavaglia Barbara, Sangiorgi Simonetta, Carelli Valerio, Torroni Antonio, Albanese Alberto, Zeviani Massimo

Abstract excerpt

It has been proposed that European mitochondrial DNA (mtDNA) haplogroups J and K, and their shared 10398G single-nucleotide polymorphism (SNP) in the ND3 gene, are protective from Parkinson's disease (PD). We evaluated the distribution of the different mtDNA haplogroups in a large cohort of 620 Italian patients with adult-onset (>50, <65 years of age) idiopathic PD vs two groups of ethnic-matched controls....

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PMID: 15827561
DOI: 10.1038/sj.ejhg.5201425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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