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Article

A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.

Blood - 1 Jul 2010

Burns Siobhan O, Killock David J, Moulding Dale A, Metelo Joao, Nunes Joao, Taylor Ruth R, Forge Andrew, Thrasher Adrian J, Ivetic Aleksandar

Abstract excerpt

Leukocytes rely on dynamic actin-dependent changes in cell shape to pass through blood vessels, which is fundamental to immune surveillance. Wiskott-Aldrich Syndrome protein (WASp) is a hematopoietic cell-restricted cytoskeletal regulator important for modulating cell shape through Arp2/3-mediated actin polymerization. A recently identified WASp(I294T) mutation was shown to render WASp constitutively active in...

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Identifiers

PMID: 20354175
DOI: 10.1182/blood-2009-08-236174
PMCID: PMC2951698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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