Article
Wiskott-Aldrich Syndrome: a model for defective actin reorganization, cell trafficking and synapse formation.
Current opinion in immunology - 1 Oct 2003
Notarangelo Luigi D, Ochs Hans D
Abstract excerpt
Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by thrombocytopenia with small platelets, eczema, recurrent infections, autoimmune disorders and increased incidence of malignancies. Classic WAS, and a milder form, X-linked thrombocytopenia, are caused by mutations of the WAS protein (WASP) gene. Recent investigations have provided evidence that WASP and several related proteins are...
Topics
- Actins
- Biological Transport
- Genetic Therapy
- Humans
- Mutation
- Proteins
- Signal Transduction
- Synapses
- Wiskott-Aldrich Syndrome
- Wiskott-Aldrich Syndrome Protein