Article
The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.
Annual review of immunology - 1 Jan 1999
Snapper S B, Rosen F S
Abstract excerpt
The Wiskott-Aldrich Syndrome (WAS) is a rare X-linked primary immunodeficiency that is characterized by recurrent infections, hematopoietic malignancies, eczema, and thrombocytopenia. A variety of hematopoietic cells are affected by the genetic defect, including lymphocytes, neutrophils, monocytes, and platelets. Early studies noted both signaling and cytoskeletal abnormalities in lymphocytes from WAS patients....
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