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Article

Mechanisms of WASp-mediated hematologic and immunologic disease.

Blood - 1 Dec 2004

Burns Siobhan, Cory Giles O, Vainchenker William, Thrasher Adrian J

Abstract excerpt

The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of actin polymerization in hematopoietic cells. The dynamic nature of cytoskeletal changes during a variety of cellular processes demands complex mechanisms for coordinated integration of input signals, precise localization within the cell, and regulated activation of the Arp2/3 complex. Mutations in the Wiskott-Aldrich syndrome gene either inhibit or...

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Identifiers

PMID: 15308573
DOI: 10.1182/blood-2004-04-1678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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