Article
The Wiskott-Aldrich syndrome: disordered actin dynamics in haematopoietic cells.
Immunological reviews - 1 Dec 2000
Thrasher A J, Burns S, Lorenzi R, Jones G E
Abstract excerpt
The Wiskott-Aldrich syndrome protein (WASp) is a member of a unique family whose members share similar domain structures and are responsible for the transduction of signals from the cell membrane to the actin cytoskeleton. For WASp, the interactions with Rho family GTPases and the cytoskeletal organising complex Arp2/3 are critical to these functions, which when disturbed translate into abnormalities of...
Topics
- Actins
- Binding Sites
- Cell Adhesion
- Cytoskeleton
- Female
- Genetic Linkage
- Hematopoietic System
- Humans
- Male
- Phagocytosis
- Phenotype
- Protein Structure, Tertiary