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Wiskott-Aldrich syndrome iPS cells produce megakaryocytes with defects in cytoskeletal rearrangement and proplatelet formation.

Thrombosis and haemostasis - 1 Apr 2015

Ingrungruanglert Praewphan, Amarinthnukrowh Pramuk, Rungsiwiwut Ruttachuk, Maneesri-le Grand Supang, Sosothikul Darintr, Suphapeetiporn Kanya, Israsena Nipan, Shotelersuk Vorasuk

Abstract excerpt

Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterised by microthrombocytopenia, complex immunodeficiency, autoimmunity, and haematologic malignancies. It is caused by mutations in the gene encoding WAS protein (WASP), a regulator of actin cytoskeleton and chromatin structure in various blood cell lineages. The molecular mechanisms underlying microthrombocytopenia caused by WASP mutations...

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PMID: 25518736
DOI: 10.1160/TH14-06-0503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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