Article
Understanding immunoactinopathies: A decade of research on WAS gene defects.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Apr 2023
Vieira Rhaissa Calixto, Pinho Lia Goncalves, Westerberg Lisa S
Abstract excerpt
Immunoactinopathies caused by mutations in actin-related proteins are a growing group of inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin cytoskeleton and affect hematopoietic cells especially because of their unique capacity to survey the body for invading pathogens and altered self, such as cancer cells. These cell motility and cell-to-cell interaction properties depend on...
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