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Article

Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction.

Cellular and molecular life sciences : CMLS - 1 Jul 2010

Stock Kristin, Nolden Lars, Edenhofer Frank, Quandel Tamara, Brüstle Oliver

Abstract excerpt

In contrast to conventional gene transfer strategies, the direct introduction of recombinant proteins into cells bypasses the risk of insertional mutagenesis and offers an alternative to genetic intervention. Here, we explore whether protein transduction of the gliogenic transcription factor Nkx2.2 can be used to promote oligodendroglial differentiation of mouse embryonic stem cell (ESC)-derived neural stem cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20352468
DOI: 10.1007/s00018-010-0347-1
PMCID: PMC2889284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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