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Article

Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.

Cell death & disease - 1 Mar 2021

Liu Fei, Zhang Yijie, Chen Fuliang, Yuan Jiacheng, Li Sanlan, Han Sue, Lu Dengyu, Geng Junlan, Rao Zhiping, Sun Li, Xu Jianhua, Shi Yuhan, Wang Xiaojing, Liu Yueguang

Abstract excerpt

Conversion of astrocytes into neurons in vivo offers an alternative therapeutic approach for neuronal loss after injury or disease. However, not only the efficiency of the conversion of astrocytes into functional neurons by single Neurog2, but also the conundrum that whether Neurog2-induced neuronal cells (Neurog2-iNs) are further functionally integrated into existing matured neural circuits remains unknown....

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Identifiers

PMID: 33649354
DOI: 10.1038/s41419-021-03498-x
PMCID: PMC7921562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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