Article
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.
Development (Cambridge, England) - 1 Feb 2014
Zhu Qiang, Zhao Xiaofeng, Zheng Kang, Li Hong, Huang Hao, Zhang Zunyi, Mastracci Teresa, Wegner Michael, Chen Yiping, Sussel Lori, Qiu Mengsheng
Abstract excerpt
In the central nervous system (CNS), oligodendrocyte maturation and axonal myelination occur on a predictable schedule, but the underlying timing mechanisms are largely unknown. In the present study, we demonstrate that Nkx2.2 homeodomain transcription factor is a key regulator for the timing of oligodendrocyte differentiation during development. Whereas induced expression of Nkx2.2 in early oligodendrocyte...
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