Article
Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure.
Cardiovascular drugs and therapy - 1 Feb 2010
Metra Marco, Covolo Loredana, Pezzali Natalia, Zacà Valerio, Bugatti Silvia, Lombardi Carlo, Bettari Luca, Romeo Alessia, Gelatti Umberto, Giubbini Raffaele, Donato Francesco, Dei Cas Livio
Abstract excerpt
BACKGROUND: Beta-blockers are mainstay of current treatment of heart failure (HF). Beta-adrenergic receptors (AR) single nucleotide gene polymorphisms (SNPs) may influence the sensitivity and density of beta-AR. We assessed the relation between three common beta-AR SNPs and the response to carvedilol administration. METHODS AND RESULTS: We studied 183 consecutive patients with chronic HF due to ischemic or...
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