Article
Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure.
Pharmacogenetics - 1 Jul 2003
Kaye David M, Smirk Belinda, Williams Carolyn, Jennings Garry, Esler Murray, Holst Dianne
Abstract excerpt
Although the widespread introduction of beta-adrenoceptor antagonists into the management of congestive heart failure (CHF) has led to significant improvements in morbidity and mortality, it is also apparent that clinical responses to this therapy vary substantially. With the recognition that functionally significant genetic polymorphisms of the beta2-adrenoceptor exist with clinically relevant allelic frequency,...
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