β-adrenergic receptor polymorphisms in susceptibility, response to treatment and prognosis in heart failure: implication of ethnicity.

doi:10.3892/mmr.2012.1120

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Article

β-adrenergic receptor polymorphisms in susceptibility, response to treatment and prognosis in heart failure: implication of ethnicity.

Molecular medicine reports - 1 Jan 2013

Pereira Sabrina Bernardez, Velloso Mônica Wanderley Monçores, Chermont Sérgio, Quintão Mônica Maria Pena, Nunes Abdhala Rosemery, Giro Camila, Oliveira E Alves Thiago, Camacho Viviane, De Fátima Maia Contarato Luiza, Pena Felipe Montes, Balieiro Henrique Miller, Garcia Maria Luiza Rosa, Da Nóbrega Antônio Cláudio Lucas, Ribeiro Georgina Severo, Mesquita Evandro Tinoco

Abstract excerpt

Common functional polymorphisms in β-adrenergic receptor (βAR) genes have been associated with heart failure (HF) phenotypes and pharmacogenetic interactions with βAR blockers. This study evaluated the association between βAR polymorphisms and carvedilol drug response and prognosis in patients with HF. In this prospective cohort controlled study, 326 volunteers were enrolled [146 HF patients (ejection fraction...

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PMID: 23064657
DOI: 10.3892/mmr.2012.1120

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