Article
Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol.
Pharmacogenetics and genomics - 1 Nov 2007
Chen Lu, Meyers Deborah, Javorsky George, Burstow Darryl, Lolekha Pakorn, Lucas Margaret, Semmler Annalese B T, Savarimuthu Santiyagu M, Fong Kwun M, Yang Ian A, Atherton John, Galbraith Andrew J, Parsonage William A, Molenaar Peter
Abstract excerpt
OBJECTIVE: Administration of the beta-adrenergic receptor blocker carvedilol to patients with chronic heart failure leads to clinically significant benefits, including improvement in left ventricular systolic function in some, but not all, patients. We sought to determine the basis of the variable effect obtained with carvedilol in patients with heart failure. Carvedilol blocks both beta1-adrenergic and...
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