Article
Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.
Heart failure clinics - 1 Jan 2010
Liggett Stephen B
Abstract excerpt
The major pathologic beta(1)-adrenergic receptor (beta(1)-AR) subtype in heart failure is beta(1)-AR. The authors' laboratory has thus pursued genetic variation of the beta(1)-AR gene at the molecular, cellular, physiologic, and clinical levels as the potential basis for interindividual variability in the response to beta-blocker treatment during heart failure. This article reviews these findings, with emphasis...
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