Article
Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2010
Tu J-H, Hu D-L, Dai L-L, Sun Y, Fan L, Zhang M, Tan Z-R, Chen Y, Li Z, Zhou H-H
Abstract excerpt
The objective of this study was to investigate the interaction between glycyrrhizin and omeprazole and observe the effects of glycyrrhizin on CYP2C19 and CYP3A4 activities in healthy Chinese male volunteers with different CYP2C19 genotypes. Eighteen healthy subjects (six CYP2C19*1/*1, five CYP2C19*1/*2, one CYP2C19*1/*3, five CYP2C19*2/*2 and one CYP2C19*2/*3) were enrolled in a two-phase randomized crossover...
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