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Article

Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms.

Journal of clinical pharmacology - 1 May 2009

Chen B L, Chen Y, Tu J H, Li Y L, Zhang W, Li Q, Fan L, Tan Z R, Hu D L, Wang D, Wang L S, Ouyang D S, Zhou H H

Abstract excerpt

This study explores the impact of clopidogrel on the pharmacokinetics of omeprazole related to CYP2C19 genetic polymorphisms. Twelve healthy volunteers (6 CYP2C19*1/*1, 5 CYP2C19*2/*2, and 1 CYP2C19*2/*3) are enrolled in a 2-phase randomized crossover trial. In each phase, the volunteers are administered a single oral dose of omeprazole 40 mg after pretreatment of either placebo or clopidogrel (300 mg on the...

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Identifiers

PMID: 19398604
DOI: 10.1177/0091270009333016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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