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Article

The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers.

European journal of clinical pharmacology - 1 Jul 2013

Yamada Satoshi, Shiohira Hideo, Yasui-Furukori Norio, Tateishi Tomonori, Akamine Yumiko, Uno Tsukasa

Abstract excerpt

PURPOSE: Omeprazole has (R)- and (S)-enantiomers, which exhibit different pharmacokinetics (PK) among patients with cytochrome P450 (CYP) 2C19 genotype groups. The aim of this study was to investigate whether the 1-point, 4-h postdose (R)-omeprazole hydroxylation index (HI) of racemic omeprazole reflects the three CYP2C19 genotype groups in Japanese individuals. METHODS: Ninety healthy Japanese individuals were...

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PMID: 23435615
DOI: 10.1007/s00228-013-1480-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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