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Article

The role of cytochrome P2C19 in R-warfarin pharmacokinetics and its interaction with omeprazole.

Therapeutic drug monitoring - 1 Jun 2008

Uno Tsukasa, Sugimoto Katsuyoshi, Sugawara Kazunobu, Tateishi Tomonori

Abstract excerpt

Previous studies reported omeprazole to be an inhibitor of cytochrome P450 (CYP) 2C19 and suggested the pharmacokinetic interaction of omeprazole with R-warfarin. The aim of this study was to compare possible effects of omeprazole on the stereoselective pharmacokinetics and pharmacodynamics of warfarin between CYP2C19 genotypes. Seventeen subjects, of whom 10 were homozygous extensive metabolizers (hmEMs) and...

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Source

Identifiers

PMID: 18520598
DOI: 10.1097/FTD.0b013e31816e2d8e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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