Article
Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Rosario Carla O, Ko Michael A, Haffani Yosr Z, Gladdy Rebecca A, Paderova Jana, Pollett Aaron, Squire Jeremy A, Dennis James W, Swallow Carol J
Abstract excerpt
Aneuploidy is a characteristic feature of established cancers and can promote tumor development. Aneuploidy may arise directly, through unequal distribution of chromosomes into daughter cells, or indirectly, through a tetraploid intermediate. The polo family kinase Plk4/Sak is required for late mitotic progression and is haploinsufficient for tumor suppression in mice. Here we show that loss of heterozygosity...
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