Article
Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
Molecular brain - 4 Nov 2008
Yang Ting, Arslanova Dilyara, Gu Yongli, Augelli-Szafran Corinne, Xia Weiming
Abstract excerpt
BACKGROUND: Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (APP). In addition to APP, γ-secretase also cleaves other type I integral membrane proteins, including the Notch receptor, a key molecule involved in embryonic development. RESULTS: To explore selective γ-secretase inhibitors, a...
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