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Article

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.

Journal of neuroscience research - 1 Nov 2003

Petit A, Pasini A, Alves Da Costa C, Ayral E, Hernandez J F, Dumanchin-Njock C, Phiel C J, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F

Abstract excerpt

gamma-Secretase activity is involved in the generation of Abeta and therefore likely contributes to the pathology of Alzheimer's disease. Blocking this activity was seen as a major therapeutic target to slow down or arrest Abeta-related AD progression. This strategy seemed more doubtful when it was established that gamma-secretase also targets other substrates including Notch, a particularly important...

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Source

Identifiers

PMID: 14598313
DOI: 10.1002/jnr.10747

Genes

APP
BACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.PMID 14598313Read ↗

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The search for gamma-secretase and development of inhibitors.Semantic proximity Read ↗

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