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Developing <i>in vivo</i> assays for investigation of p75 <sup>NTR</sup> and NRH1 transmembrane domain cleavage events using zebrafish embryos

2020-05-04

Abstract excerpt

γ-secretase is an important protease complex responsible for the cleavage of over 100 substrates within their transmembrane domains. γ-secretase acts in Alzheimer’s disease by cleavage of AMYLOID BETA (A4) PRECURSOR PROTEIN to produce aggregation-prone Amyloid beta peptide. Other γ-secretase substrates such as p75 NTR are also relevant to Alzheimer’s disease. How γ-secretase cleavage site specificity is determine...

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Literature Corpus work
c81c2c0e-8128-58b1-b27e-9d78bedd5c8d
DOI
10.1101/2020.05.04.076539
Open publication

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Developing <i>in vivo</i> assays for investigation of p75 <sup>NTR</sup> and NRH1 transmembrane domain cleavage events using zebrafish embryosDOI 10.1101/2020.05.04.076539
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