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Article

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes.

Journal of neurochemistry - 1 Nov 2013

van Bebber Frauke, Hruscha Alexander, Willem Michael, Schmid Bettina, Haass Christian

Abstract excerpt

Alzheimer's disease is the most frequent dementia. Pathologically, Alzheimer's disease is characterized by the accumulation of senile plaques composed of amyloid β-peptide (Aβ). Two proteases, β- and γ-secretase proteolytically generate Aβ from its precursor, the ß-amyloid precursor protein (APP). Inhibition of β-secretase, also referred to as beta-site APP cleaving enzyme (BACE1) or γ-secretase is therefore of...

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Share to Amyloid Precursor Protein Secretases
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Melanocytes

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Source

Identifiers

PMID: 23406323
DOI: 10.1111/jnc.12198

Genes

BACE1
APP
BACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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