Article
No association of alcohol dependence with HOMER 1 and 2 genetic variants.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2010
Preuss U W, Ridinger M, Rujescu D, Fehr C, Koller G, Wodarz N, Bondy B, Soyka M, Wong W M, Zill P
Abstract excerpt
Several lines of evidence indicate that alterations of the central cortico-accumbens glutamate pathway are involved in the development and maintenance of alcohol- and substance-use disorders. The HOMER protein family is encoded by 3 genes HOMER (1-3) which are components of the excitatory postsynaptic density complex and function to modulate synaptic activity by the regulation of glutamate signaling. HOMER 1 and...
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