Article
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.
Archives of general psychiatry - 1 Sept 2002
Lappalainen Jaakko, Kranzler Henry R, Malison Robert, Price Lawrence H, Van Dyck Christopher, Rosenheck Robert A, Cramer Joyce, Southwick Steven, Charney Dennis, Krystal John, Gelernter Joel
Abstract excerpt
BACKGROUND: Quantitative trait locus studies, and observations in animals manipulated for the neuropeptide Y (NPY) gene suggest that variation within this gene may contribute to alcoholism. A recent population study suggested that the Pro7 allele of a functional NPY polymorphism (Leu7Pro) may be associated with increased alcohol consumption. We tested whether the Pro7 allele is associated with alcohol dependence...
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