Article
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
Archives of general psychiatry - 1 Jul 2008
Schumann Gunter, Johann Monika, Frank Josef, Preuss Ulrich, Dahmen Norbert, Laucht Manfred, Rietschel Marcella, Rujescu Dan, Lourdusamy Anbarasu, Clarke Toni-Kim, Krause Kristina, Dyer Anne, Depner Martin, Wellek Stefan, Treutlein Jens, Szegedi Armin, Giegling Ina, Cichon Sven, Blomeyer Dorothea, Heinz Andreas, Heath Simon, Lathrop Mark, Wodarz Norbert, Soyka Michael, Spanagel Rainer, Mann Karl
Abstract excerpt
CONTEXT: Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models. OBJECTIVE: To investigate whether genetic variations in glutamatergic neurotransmission genes, which are known to alter alcohol effects in rodents, contribute to the genetic basis of alcoholism in humans. DESIGN: Association analysis of alcohol dependence and haplotype-tagging single nucleotide polymorphisms...
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