Article
Mutation screen of the GAD2 gene and association study of alcoholism in three populations.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2007
Lappalainen Jaakko, Krupitsky Evgeny, Kranzler Henry R, Luo Xingguang, Remizov Mikhail, Pchelina Sofia, Taraskina Anastaisa, Zvartau Edwin, Räsanen Pirkko, Makikyro Taru, Somberg Lucia K, Krystal John H, Stein Murray B, Gelernter Joel
Abstract excerpt
Synaptic actions of gamma-amino butyric acid (GABA) have been implicated in many facets of ethanol's effects and risk for alcoholism. We examined whether variation in glutamate decarboxylase-2 (GAD2), a gene encoding for a major enzyme in the synthesis of GABA, contributes to risk of alcohol depe...
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