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Article

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.

PLoS genetics - 19 Mar 2010

Slack Cathy, Werz Christian, Wieser Daniela, Alic Nazif, Foley Andrea, Stocker Hugo, Withers Dominic J, Thornton Janet M, Hafen Ernst, Partridge Linda

Abstract excerpt

Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domains, thus playing a critical role in signal transduction from receptor tyrosine kinases to form protein networks. Physiological studies of SH2B function in mammals have...

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PMID: 20333234
DOI: 10.1371/journal.pgen.1000881
PMCID: PMC2841611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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