Article
Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2010
Hsu Fang-Chi, Sun Jielin, Zhu Yi, Kim Seong-Tae, Jin Tao, Zhang Zheng, Wiklund Fredrik, Kader A Karim, Zheng S Lilly, Isaacs William, Grönberg Henrik, Xu Jianfeng
Abstract excerpt
Disease risk-associated single nucleotide polymorphisms (SNP) identified from genome-wide association studies have the potential to be used for disease risk prediction. An important feature of these risk-associated SNPs is their weak individual effect but stronger cumulative effect on disease risk. Several approaches are commonly used to model the combined effect in risk prediction, but their performance is...
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