Article
Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.
Cancer research - 1 Jun 1991
Tamura G, Kihana T, Nomura K, Terada M, Sugimura T, Hirohashi S
Abstract excerpt
Mutations of the p53 gene were investigated after tumor cell enrichment by cell sorting based on differences in DNA content and polymerase chain reaction single-strand conformation polymorphism analysis in 24 surgical specimens of primary gastric cancer. p53 mutations were detected in exons 4-8 i...
Topics
- Base Sequence
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA, Single-Stranded
- Exons
- Flow Cytometry
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Stomach Neoplasms