Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene.

Article

Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene.

Oncogene - 1 Jun 1994

Moyret C, Theillet C, Puig P L, Molés J P, Thomas G, Hamelin R

Abstract excerpt

p53 is the most commonly mutated gene in a large variety of human tumors including familial cancers. Because p53 mutations have in a number of human cancer types, been related to a negative outcome of the disease and the importance of pre-symptomatic diagnosis in cancer-prone families, screening...

Topics

Base Sequence
Electrophoresis
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation
Polymorphism, Genetic

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