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Article

Altered expression of transforming growth factor-alpha in hereditary rat renal cell carcinoma.

Cancer research - 1 Jun 1991

Walker C, Everitt J, Freed J J, Knudson A G, Whiteley L O

Abstract excerpt

A hereditary form of renal cell carcinoma exists in rats that results from a single gene mutation and is histologically similar to that described in humans. Cell lines derived from these rat tumors were shown to express abundant transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF)-receptor RNA transcripts, but no EGF mRNA. In contrast, normal kidney expressed EGF and EGF-receptor...

Topics

Animals
Carcinoma, Renal Cell
Epidermal Growth Factor
ErbB Receptors
Kidney
Kidney Neoplasms
Phenotype
RNA, Messenger
Rats
Transforming Growth Factor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2032234

Genes

EGF
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2032234-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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