Article
A null model for the distribution of fitness effects of mutations.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2023
Cotto Olivier, Day Troy
Abstract excerpt
The distribution of fitness effects (DFE) of new mutations is key to our understanding of many evolutionary processes. Theoreticians have developed several models to help understand the patterns seen in empirical DFEs. Many such models reproduce the broad patterns seen in empirical DFEs but these models often rely on structural assumptions that cannot be tested empirically. Here, we investigate how much of the...
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