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Dynamics of the distribution of fitness effects during adaptation.

Theoretical population biology - 1 Dec 2025

Morales Tenoch, Kushnir Abigail, Wahl Lindi M

Abstract excerpt

Empirical measures of the distribution of fitness effects of new mutations (the DFE) have been increasingly successful, and have recently highlighted the fact that the DFE changes during adaptation. Here, we analyze these dynamic changes to the DFE during a simplified adaptive process: an adaptive walk across an additive fitness landscape. First, we derive analytical approximations for the underlying fitness...

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PMID: 40992698
DOI: 10.1016/j.tpb.2025.09.003

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