Article
Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.
Human immunology - 1 Jun 2010
Izakovicova Holla Lydie, Hrdlicková Barbara, Schüller Marcel, Buckova Dana, Kindlova Dagmar, Izakovic Vincent, Vasku Anna
Abstract excerpt
The interleukin-18 (IL-18) gene on chromosome 11q22 has been suggested as a susceptibility factor for allergies. To test for a possible role of IL-18 polymorphisms in Czech population, case-control study including 958 subjects (633 allergic patients and 325 healthy controls) was performed. An allele-specific polymerase chain reaction was used to analyze variants at positions -607 C/A (rs1946518) and -137 G/C...
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