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Article

Decreasing the homodimer interaction: a common mechanism shared by the deltaG91 mutation and deamidation in betaA3-crystallin.

Molecular vision - 16 Mar 2010

Xu Jianzhen, Wong Chiwai, Tan Xiaorong, Jing Hongjuan, Zhou Guangzhou, Song Wei

Abstract excerpt

PURPOSE: Cataracts can be broadly divided into two types: congenital cataracts and age-related cataracts. DeltaG91 is a previously discovered congenital mutation in betaA3-crystallin that impairs protein solubility. On the other hand, the deamidation of beta-crystallin is a significant feature in aged and cataractous lenses. Several deamidation sites were also identified in betaA3-crystallin. The present study is...

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PMID: 20300566
PMCID: PMC2838740

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